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Chapter 12:  Putting it all together

Knowing, at a biological level, that a big part of the problem is "not your fault", might be at least part of the toolset you can use to get better -- or at least suffer less with what you've got.  Perhaps it will help, at least somewhat, to keep your own mind from making things worse.  I hope that turns out to be true for you.  

Here are the key concepts for each chapter, all in a row, so you can review what you've learned, with a link for each if you'd like to review.  After that I'll offer a few thoughts on the whole picture, and link you to more resources, which I'll add here over time as this story changes -- which it surely will, perhaps faster than any other mental story, thanks to the efforts of the many researchers whose work is displayed here. 

Chapter 1

Chapter 2

Chapter 3

Chapter 4

Chapter 5
Although it might seem like knowing which allele lengths you have would be a great thing, there are some reasons to be cautious.  Here are some pros and cons.  

Chapter 6

Cellular Connections During Mood Disorders  

Results of Effective Treatments

Chapter 7:  
Stress causes the normal production of new neurons in the hippocampus ("neurogenesis") to slow or stop; and it may be that antidepressants work by accelerating that process.  

Chapter 8

Chapter 9

Chapter 10

Chapter 11

Antidepressant treatments and lithium lead to mprovements in structure (before lithium above, after lithium below) 

and in function (perhaps directly related to the structural changes, but welcome in any case) : 


Before Treatment
After Treatment
Logical Memory
28 +/-  7
18 +/- 9
27 +/-  8


Concuding Thoughts

Under construction Feb 2005 

(I'm going to take a breather before returning to muse on all this), including things like: 

Meanwhile, for more details from Dr. Manji's work, here he is in person in a long interview he granted to a great support group: his interview with CABF (The Child and Adolescent Bipolar Foundation).